首页> The Journal of biological chemistry> The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

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第一作者： Carmen,Bergom

第一单位： From the Cancer Center, the Departments of Radiation Oncology, cbergom@mcw.edu.

作者： Carmen,Bergom ^[1] ; Andrew D,Hauser ^[2] ; Amy,Rymaszewski ^[3] ; Patrick,Gonyo ^[3] ; Jeremy W,Prokop ^[4] ; Benjamin C,Jennings ^[5] ; Alexis J,Lawton ^[6] ; Anne,Frei ^[7] ; Ellen L,Lorimer ^[3] ; Irene,Aguilera-Barrantes ^[8] ; Alexander C,Mackinnon ^[9] ; Kathleen,Noon ^[10] ; Carol A,Fierke ^[11] ; Carol L,Williams ^[3]

作者单位： From the Cancer Center, the Departments of Radiation Oncology, cbergom@mcw.edu. ^[1] From the Cancer Center, the Departments of Radiation Oncology, Pharmacology and Toxicology, and the Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016, and. ^[2] From the Cancer Center, Pharmacology and Toxicology, and. ^[3] the Human and Molecular Genetics Center, and. ^[4] the Department of Chemistry. ^[5] the Department of Chemistry, Biochemistry Undergraduate Program, and. ^[6] From the Cancer Center, the Departments of Radiation Oncology. ^[7] Pathology. ^[8] From the Cancer Center, Pathology. ^[9] the Mass Spectroscopy Facility for Proteomics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226. ^[10] the Department of Chemistry, Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109. ^[11]

关键词 Di-Ras1 GTPase Kras (KRAS)NF-kappaB (NF-KB)Rap1GDS1 Ras homolog gene family, member A (RhoA)Ras-related protein 1 (Rap1)Rig SmgGDS breast cancer glioblastoma