Cholesterol modulates Orai1 channel function.-论文-万方医学网

作者： Isabella,Derler ^[1] ; Isaac,Jardin ^[2] ; Peter B,Stathopulos ^[3] ; Martin,Muik ^[2] ; Marc,Fahrner ^[2] ; Vasilina,Zayats ^[4] ; Saurabh K,Pandey ^[4] ; Michael,Poteser ^[5] ; Barbara,Lackner ^[2] ; Marketa,Absolonova ^[2] ; Rainer,Schindl ^[2] ; Klaus,Groschner ^[5] ; Rüdiger,Ettrich ^[4] ; Mitsu,Ikura ^[6] ; Christoph,Romanin ^[1]

作者单位： Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria. isabella.derler@jku.at christoph.romanin@jku.at. ^[1] Institute of Biophysics, Johannes Kepler University of Linz, Gruberstrasse 40, 4020 Linz, Austria. ^[2] Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada. ^[3] Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, CZ-373 33 Nové Hrady, Czech Republic. ^[4] Institute of Biophysics, Medical University of Graz, Harrachgasse 21/4, 8010 Graz, Austria. ^[5] Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada. ^[6]

主题词生物素化作用(Biotinylation);钙(Calcium);钙通道(Calcium Channels);细胞系(Cell Line);细胞膜(Cell Membrane);胆固醇(Cholesterol);胆固醇氧化酶类(Cholesterol Oxidase);圆二色性(Circular Dichroism);电生理学现象(Electrophysiological Phenomena);荧光共振能量转移(Fluorescence Resonance Energy Transfer);HEK293细胞(HEK293 Cells);组胺(Histamine);人类(Humans);肥大细胞(Mast Cells);突变(Mutation);肽类(Peptides);点突变(Point Mutation);蛋白质结构, 三级(Protein Structure, Tertiary);信号传导(Signal Transduction);光谱法, 荧光(Spectrometry, Fluorescence)

DOI 10.1126/scisignal.aad7808

PMID 26814231

发布时间 2021-06-16

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Cholesterol modulates Orai1 channel function.

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Cholesterol modulates Orai1 channel function.

Science signaling

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Science signaling

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