CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.

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作者： Shu,Su ^[1] ; Bian,Hu ^[2] ; Jie,Shao ^[1] ; Bin,Shen ^[3] ; Juan,Du ^[1] ; Yinan,Du ^[2] ; Jiankui,Zhou ^[2] ; Lixia,Yu ^[1] ; Lianru,Zhang ^[1] ; Fangjun,Chen ^[1] ; Huizi,Sha ^[1] ; Lei,Cheng ^[1] ; Fanyan,Meng ^[1] ; Zhengyun,Zou ^[1] ; Xingxu,Huang ^[2] ; Baorui,Liu ^[4]

作者单位： The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University &Clinical Cancer Institute of Nanjing University, Nanjing 210008, China. ^[1] MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, National Resource Center for Mutant Mice, Nanjing 210061, China. ^[2] State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, China. ^[3] School of Life Science and Technology, ShanghaiTech University, 100 Haike Rd., Pudong New Area, Shanghai 201210, China. ^[4]

主题词碱基序列(Base Sequence);细胞, 培养的(Cells, Cultured);细胞因子类(Cytokines);细胞毒性, 免疫(Cytotoxicity, Immunologic);基因敲除技术(Gene Knockout Techniques);基因顺序(Gene Order);基因打靶(Gene Targeting);基因转移技术(Gene Transfer Techniques);基因座(Genetic Loci);遗传载体(Genetic Vectors);人类(Humans);淋巴细胞活化(Lymphocyte Activation);肿瘤(Neoplasms);表型(Phenotype);T淋巴细胞亚群(T-Lymphocyte Subsets);转染(Transfection)

DOI 10.1038/srep20070

PMID 26818188

发布时间 2024-01-04

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CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.

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CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.

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