7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action.-论文-万方医学网

作者： Pavla,Perlíková ^[1] ; Gabriela,Rylová ^[2] ; Petr,Nauš ^[1] ; Tomáš,Elbert ^[1] ; Eva,Tloušťová ^[1] ; Aurelie,Bourderioux ^[1] ; Lenka Poštová,Slavětínská ^[1] ; Kamil,Motyka ^[3] ; Dalibor,Doležal ^[2] ; Pawel,Znojek ^[2] ; Alice,Nová ^[2] ; Monika,Harvanová ^[2] ; Petr,Džubák ^[2] ; Michal,Šiller ^[2] ; Jan,Hlaváč ^[4] ; Marián,Hajdúch ^[5] ; Michal,Hocek ^[6]

作者单位： Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Prague, Czech Republic. ^[1] Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Olomouc, Czech Republic. ^[2] Department of Organic Chemistry, Faculty of Natural Sciences, Palacky University, Olomouc, Czech Republic. ^[3] Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Olomouc, Czech Republic. Department of Organic Chemistry, Faculty of Natural Sciences, Palacky University, Olomouc, Czech Republic. ^[4] Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Olomouc, Czech Republic. hocek@uochb.cas.cz marian.hajduch@upol.cz. ^[5] Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Gilead Sciences & IOCB Research Center, Prague, Czech Republic. Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic. hocek@uochb.cas.cz marian.hajduch@upol.cz. ^[6]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞膜通透性(Cell Membrane Permeability);细胞增殖(Cell Proliferation);DNA(DNA);DNA损伤(DNA Damage);疾病模型, 动物(Disease Models, Animal);成纤维细胞(Fibroblasts);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);小鼠(Mice);肿瘤(Neoplasms);蛋白质生物合成(Protein Biosynthesis);蛋白质折叠(Protein Folding);RNA, 信使(RNA, Messenger);存活率分析(Survival Analysis);治疗结果(Treatment Outcome);杀结核菌素(Tubercidin);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/1535-7163.MCT-14-0933

PMID 26819331

发布时间 2020-09-30

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7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action.

Molecular cancer therapeutics

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Molecular cancer therapeutics

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7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action.

Molecular cancer therapeutics

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Molecular cancer therapeutics

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