Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

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作者： Santhosh F,Neelamkavil ^[1] ; Sony,Agrawal ^[1] ; Thomas,Bara ^[1] ; Chad,Bennett ^[1] ; Sathesh,Bhat ^[1] ; Dipshikha,Biswas ^[1] ; Linda,Brockunier ^[1] ; Nicole,Buist ^[1] ; Duane,Burnette ^[1] ; Mark,Cartwright ^[1] ; Samuel,Chackalamannil ^[1] ; Robert,Chase ^[1] ; Mariappan,Chelliah ^[1] ; Austin,Chen ^[1] ; Martin,Clasby ^[1] ; Vincent J,Colandrea ^[1] ; Ian W,Davies ^[1] ; Keith,Eagen ^[1] ; Zhuyan,Guo ^[1] ; Yongxin,Han ^[1] ; John,Howe ^[1] ; Charles,Jayne ^[1] ; Hubert,Josien ^[1] ; Stacia,Kargman ^[1] ; Karen,Marcantonio ^[1] ; Shouwu,Miao ^[1] ; Randy,Miller ^[1] ; Andrew,Nolting ^[1] ; Patrick,Pinto ^[1] ; Murali,Rajagopalan ^[1] ; Rebecca T,Ruck ^[1] ; Unmesh,Shah ^[1] ; Aileen,Soriano ^[1] ; Donald,Sperbeck ^[1] ; Francisco,Velazquez ^[1] ; Jin,Wu ^[1] ; Yan,Xia ^[1] ; Srikanth,Venkatraman ^[1]

作者单位： Merck Research Laboratories , Kenilworth, New Jersey 07033, United States. ^[1]

关键词 Antiviral HCV MK-5172 MK-8831 NS3/4a genotype 3a macrocycle pan-genotypic

DOI 10.1021/acsmedchemlett.5b00425

PMID 26819676

发布时间 2020-10-01

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