Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells.

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作者： Lee M,Butcher ^[1] ; Mitsuteru,Ito ^[2] ; Minodora,Brimpari ^[3] ; Tiffany J,Morris ^[4] ; Filipa A C,Soares ^[1] ; Lars,Ährlund-Richter ^[5] ; Nessa,Carey ^[4] ; Ludovic,Vallier ^[6] ; Anne C,Ferguson-Smith ^[7] ; Stephan,Beck ^[8]

作者单位： UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK. ^[1] Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK. ^[2] Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. ^[3] Anne McLaren Laboratory, Department of Surgery, Wellcome Trust and Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0SZ, UK. ^[4] Cambridge Epigenetix, Jonas Webb Building, Babraham Campus, Cambridge CB22 3AT, UK. ^[5] Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. ^[6] Division of Paediatric Oncology, Department of Women's and Children's Health, Karolinska Institutet,171 76 Stockholm, Sweden. ^[7] PraxisUnico, The Jeffreys Building, St John's Innovation Park, Cambridge CB4 0DE, UK. ^[8]

主题词细胞分化(Cell Differentiation);队列研究(Cohort Studies);DNA甲基化(DNA Methylation);内胚层(Endoderm);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells)

DOI 10.1038/ncomms10458

PMID 26822956

发布时间 2024-07-10

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Nature communications

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Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells.

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Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells.

Nature communications

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