SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex.-论文-万方医学网

作者： Yoon,Park ^[1] ; Hyung-Seung,Jin ^[1] ; Justine,Lopez ^[1] ; Jeeho,Lee ^[1] ; Lujian,Liao ^[2] ; Chris,Elly ^[1] ; Yun-Cai,Liu ^[1]

作者单位： Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA. ^[1] Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China. ^[2] Institute for Immunology, Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, China. ^[3]

主题词动物(Animals);载体蛋白质类(Carrier Proteins);结肠炎(Colitis);细胞因子类(Cytokines);女(雌)性(Female);流式细胞术(Flow Cytometry);人类(Humans);免疫耐受(Immune Tolerance);免疫印迹法(Immunoblotting);免疫沉淀法(Immunoprecipitation);炎症(Inflammation);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);Jurkat细胞(Jurkat Cells);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小鼠, 转基因(Mice, Transgenic);NF-κB(NF-kappa B);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);信号传导(Signal Transduction);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);泛素化(Ubiquitination);ZAP-70蛋白酪氨酸激酶(ZAP-70 Protein-Tyrosine Kinase)

DOI 10.1038/ni.3352

PMID 26829767

发布时间 2024-06-10

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SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex.

Nature immunology

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Nature immunology

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SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex.

Nature immunology

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Nature immunology

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