PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.

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作者： Weibo,Luo ^[1] ; Ivan,Chen ^[2] ; Yan,Chen ^[3] ; Duah,Alkam ^[4] ; Yingfei,Wang ^[1] ; Gregg L,Semenza ^[3]

作者单位： Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[1] Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[2] Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA. ^[3] Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA. ^[4] Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, USA. ^[5] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[6] Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[7] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[8] Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[9] Department of McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[10]

关键词 HIFs PRDX2 PRDX4 transcriptional corepressor