O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.-论文-万方医学网

作者： Shutao,Xie ^[1] ; Nana,Jin ^[2] ; Jianlan,Gu ^[1] ; Jianhua,Shi ^[2] ; Jianming,Sun ^[1] ; Dandan,Chu ^[2] ; Liang,Zhang ^[1] ; Chun-Ling,Dai ^[1] ; Jin-Hua,Gu ^[1] ; Cheng-Xin,Gong ^[2] ; Khalid,Iqbal ^[2] ; Fei,Liu ^[1]

作者单位： Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, 226001, China. ^[1] Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, 10314, USA. ^[2]

主题词乙酰葡萄糖胺(Acetylglucosamine);阿尔茨海默病(Alzheimer Disease);动物(Animals);脑(Brain);cAMP反应元件结合蛋白质(Cyclic AMP Response Element-Binding Protein);环AMP依赖性蛋白激酶催化亚单位(Cyclic AMP-Dependent Protein Kinase Catalytic Subunits);重氮亮氨酸(Diazooxonorleucine);减量调节(Down-Regulation);糖基化(Glycosylation);HEK293细胞(HEK293 Cells);人类(Humans);学习(Learning);男(雄)性(Male);记忆(Memory);记忆障碍(Memory Disorders);小鼠, 近交C57BL(Mice, Inbred C57BL);磷酰化(Phosphorylation);蛋白质转运(Protein Transport);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);亚细胞部分(Subcellular Fractions);tau蛋白质类(tau Proteins)

DOI 10.1111/acel.12449

PMID 26840030

发布时间 2018-11-13

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O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.

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O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.

Aging cell

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Aging cell

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