Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring.

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第一作者： Fabien,Boulle

第一单位： School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200, MD, Maastricht, The Netherlands; Center for Psychiatry and Neuroscience, INSERM, U894, University Pierre and Marie Curie, Paris, France.

作者： Fabien,Boulle ^[1] ; Jodi L,Pawluski ^[2] ; Judith R,Homberg ^[3] ; Barbie,Machiels ^[4] ; Yvet,Kroeze ^[3] ; Neha,Kumar ^[4] ; Harry W M,Steinbusch ^[4] ; Gunter,Kenis ^[4] ; Daniel L A,van den Hove ^[5]

作者单位： School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200, MD, Maastricht, The Netherlands; Center for Psychiatry and Neuroscience, INSERM, U894, University Pierre and Marie Curie, Paris, France. ^[1] School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200, MD, Maastricht, The Netherlands; University of Liege, GIGA-Neurosciences, 1 avenue de l'Hôpital (Bat. B36), B-4000 Liège, Belgium. Electronic address: j.pawluski@gmail.com. ^[2] Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Radboud University Medical Centre, Department of Cognitive Neuroscience, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands. ^[3] School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200, MD, Maastricht, The Netherlands. ^[4] School for Mental Health and Neuroscience (MHeNS), Maastricht University, European Graduate School of Neuroscience (EURON), Universiteitssingel 50, P.O. box 616, 6200, MD, Maastricht, The Netherlands; Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany. ^[5]

关键词 Epigenetic Gender Hippocampus Maternal behavior Neuroplasticity Postpartum depression Prenatal stress SSRI Serotonin Sex differences