Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.-论文-万方医学网

作者： Anna,Schneider ^[1] ; Angela,Corona ^[2] ; Imke,Spöring ^[3] ; Mareike,Jordan ^[1] ; Bernd,Buchholz ^[4] ; Elias,Maccioni ^[2] ; Roberto,Di Santo ^[5] ; Jochen,Bodem ^[3] ; Enzo,Tramontano ^[2] ; Birgitta M,Wöhrl ^[6]

作者单位： Universität Bayreuth, Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universitätsstrasse 30, 95447 Bayreuth, Germany. ^[1] Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, SS 554, 09042, Monserrato, Cagliari, Italy. ^[2] Julius-Maximilians-Universität Würzburg, Institut für Virologie und Immunbiologie, Versbacher Strasse 7, 97078 Würzburg, Germany. ^[3] Universität Heidelberg, Medizinische Fakultät Mannheim, Klinik für Kinder- und Jugendmedizin, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. ^[4] Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" Università di Roma, Rome, I-00185, Italy. ^[5] Universität Bayreuth, Lehrstuhl Biopolymere und Forschungszentrum für Bio-Makromoleküle, Universitätsstrasse 30, 95447 Bayreuth, Germany birgitta.woehrl@uni-bayreuth.de. ^[6]

主题词氨基酸序列(Amino Acid Sequence);氨基酸取代(Amino Acid Substitution);抗HIV药(Anti-HIV Agents);克隆, 分子(Cloning, Molecular);双脱氧核苷酸类(Dideoxynucleotides);抗药性, 多种, 病毒(Drug Resistance, Multiple, Viral);酶抑制剂(Enzyme Inhibitors);大肠杆菌(Escherichia coli);基因表达(Gene Expression);基因型(Genotype);HIV感染(HIV Infections);HIV逆转录酶(HIV Reverse Transcriptase);HIV-1(HIV-1);人类(Humans);分子序列数据(Molecular Sequence Data);诱变, 定点(Mutagenesis, Site-Directed);突变(Mutation);重组蛋白质类(Recombinant Proteins);核糖核酸酶H, 人免疫缺陷病毒(Ribonuclease H, Human Immunodeficiency Virus);胸腺嘧啶核苷酸类(Thymine Nucleotides);齐多夫定(Zidovudine)

DOI 10.1093/nar/gkw060

PMID 26850643

发布时间 2020-12-09

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Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.

Nucleic acids research

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Nucleic acids research

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Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.

Nucleic acids research

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Nucleic acids research

相关期刊

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