Insights into length-dependent regulation of cardiac cross-bridge cycling kinetics in human myocardium.

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作者： Nima,Milani-Nejad ^[1] ; Jae-Hoon,Chung ^[1] ; Benjamin D,Canan ^[2] ; Jonathan P,Davis ^[2] ; Vadim V,Fedorov ^[2] ; Robert S D,Higgins ^[3] ; Ahmet,Kilic ^[3] ; Peter J,Mohler ^[4] ; Paul M L,Janssen ^[5]

作者单位： Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University Wexner Medical Center, USA. ^[1] Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA. ^[2] Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, USA. ^[3] Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, USA. ^[4] Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, USA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, USA. Electronic address: janssen.10@osu.edu. ^[5]

关键词 Cross-bridge cycling kinetics Muscle length Post-translational modification Rate of tension redevelopment Trabeculae