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首页> Proceedings of the National Academy of Sciences of the United States of America> Early and multiple origins of metastatic lineages within primary tumors.

Early and multiple origins of metastatic lineages within primary tumors.

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作者： Zi-Ming,Zhao ^[1] ; Bixiao,Zhao ^[2] ; Yalai,Bai ^[3] ; Atila,Iamarino ^[4] ; Stephen G,Gaffney ^[4] ; Joseph,Schlessinger ^[5] ; Richard P,Lifton ^[2] ; David L,Rimm ^[3] ; Jeffrey P,Townsend ^[6]

作者单位： Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510; Jeffrey.Townsend@Yale.edu Joseph.Schlessinger@Yale.edu Zi-ming.Zhao@Yale.edu. ^[1] Department of Genetics, Yale School of Medicine, New Haven, CT 06520; ^[2] Department of Pathology, Yale School of Medicine, New Haven, CT 06520; ^[3] Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510; ^[4] Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520; Jeffrey.Townsend@Yale.edu Joseph.Schlessinger@Yale.edu Zi-ming.Zhao@Yale.edu. ^[5] Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511 Jeffrey.Townsend@Yale.edu Joseph.Schlessinger@Yale.edu Zi-ming.Zhao@Yale.edu. ^[6]

关键词 ancestral reconstruction cancer chronograms oncogenes tumor phylogenetics

主题词细胞谱系(Cell Lineage);细胞转化, 肿瘤(Cell Transformation, Neoplastic);进化, 分子(Evolution, Molecular);女(雌)性(Female);遗传变异(Genetic Variation);人类(Humans);似然函数(Likelihood Functions);男(雄)性(Male);模型, 遗传学(Models, Genetic);突变(Mutation);肿瘤转移(Neoplasm Metastasis);肿瘤(Neoplasms);癌基因(Oncogenes);种系发生(Phylogeny);时间因素(Time Factors)

DOI 10.1073/pnas.1525677113

PMID 26858460

发布时间 2018-11-13

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2016年113卷8期

2140-5页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2016年113卷8期

2140-5页

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