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Random sample consensus combined with partial least squares regression (RANSAC-PLS) for microbial metabolomics data mining and phenotype improvement.

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第一作者： Shao Thing,Teoh

第一单位： Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: teoh_shao_thing@bio.eng.osaka-u.ac.jp.

作者： Shao Thing,Teoh ^[1] ; Miki,Kitamura ^[2] ; Yasumune,Nakayama ^[3] ; Sastia,Putri ^[4] ; Yukio,Mukai ^[5] ; Eiichiro,Fukusaki ^[6]

作者单位： Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: teoh_shao_thing@bio.eng.osaka-u.ac.jp. ^[1] Towa Pharmaceutical Co., Ltd., 26-7 Ichiban-Cho, Kadoma, Osaka 571-0033, Japan. Electronic address: m-kitamura@towayakuhin.co.jp. ^[2] Department of Applied Microbial Technology, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan. Electronic address: ynaka@bio.sojo-u.ac.jp. ^[3] Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: sastia_putri@bio.eng.osaka-u.ac.jp. ^[4] Department of Bioscience, Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan. Electronic address: y_mukai@nagahama-i-bio.ac.jp. ^[5] Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: fukusaki@bio.eng.osaka-u.ac.jp. ^[6]

关键词 1-Butanol tolerance Data mining Gas chromatography/mass spectrometry Metabolomics Partial least squares Phenotype improvement Random sample consensus Regression model Saccharomyces cerevisiae Semi-rational strain engineering