Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.-论文-万方医学网

作者： Faranak,Fattahi ^[1] ; Julius A,Steinbeck ^[2] ; Sonja,Kriks ^[3] ; Jason,Tchieu ^[1] ; Bastian,Zimmer ^[2] ; Sarah,Kishinevsky ^[1] ; Nadja,Zeltner ^[2] ; Yvonne,Mica ^[1] ; Wael,El-Nachef ^[2] ; Huiyong,Zhao ^[1] ; Elisa,de Stanchina ^[2] ; Michael D,Gershon ^[1] ; Tracy C,Grikscheit ^[2] ; Shuibing,Chen ^[3] ; Lorenz,Studer ^[1]

作者单位： The Center for Stem Cell Biology, New York, New York 10065, USA. ^[1] Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, New York, New York 10065, USA. ^[2] Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10065, USA. ^[3] Molecular Pharmacology Program, New York, New York 10065, USA. ^[4] Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. ^[5] Children's Hospital Los Angeles, Pediatric Surgery, Los Angeles, California 90027, USA. ^[6] Department of Surgery, Weill Medical College of Cornell University, New York, New York 10065, USA. ^[7]

主题词衰老(Aging);动物(Animals);细胞分化(Cell Differentiation);细胞系(Cell Line);细胞谱系(Cell Lineage);细胞运动(Cell Movement);细胞分离(Cell Separation);鸡胚(Chick Embryo);结肠(Colon);疾病模型, 动物(Disease Models, Animal);药物发现(Drug Discovery);肠神经系统(Enteric Nervous System);女(雌)性(Female);胃肠道(Gastrointestinal Tract);Hirschsprung病(Hirschsprung Disease);人类(Humans);男(雄)性(Male);小鼠(Mice);神经元(Neurons);胃酶抑素类(Pepstatins);多潜能干细胞(Pluripotent Stem Cells);受体, 内皮素B(Receptor, Endothelin B);信号传导(Signal Transduction)

DOI 10.1038/nature16951

PMID 26863197

发布时间 2018-11-13

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Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.

Nature

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Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.

Nature

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