Tackling amyloidogenesis in Alzheimer's disease with A2V variants of Amyloid-β.

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作者： Giuseppe,Di Fede ^[1] ; Marcella,Catania ^[1] ; Emanuela,Maderna ^[1] ; Michela,Morbin ^[1] ; Fabio,Moda ^[1] ; Laura,Colombo ^[2] ; Alessandro,Rossi ^[2] ; Alfredo,Cagnotto ^[2] ; Tommaso,Virgilio ^[1] ; Luisa,Palamara ^[1] ; Margherita,Ruggerone ^[1] ; Giorgio,Giaccone ^[1] ; Ilaria,Campagnani ^[1] ; Massimo,Costanza ^[3] ; Rosetta,Pedotti ^[3] ; Matteo,Salvalaglio ^[4] ; Mario,Salmona ^[2] ; Fabrizio,Tagliavini ^[1]

作者单位： Neurology V and Neuropathology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute (INCB), Via Celoria 11, 20133 Milan, Italy. ^[1] Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20158 Milan, Italy. ^[2] Neuroimmunology and Neuromuscular Disorder Unit, IRCCS Foundation "C. Besta" Neurological Institute (INCB), Via Celoria 11, 20133 Milan, Italy. ^[3] Department of Chemical Engineering, University College London, London WC1E 7JE, UK. ^[4]

主题词阿尔茨海默病(Alzheimer Disease);氨基酸取代(Amino Acid Substitution);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);脑(Brain);脑化学(Brain Chemistry);认知(Cognition);疾病模型, 动物(Disease Models, Animal);探究行为(Exploratory Behavior);女(雌)性(Female);人类(Humans);注射, 腹腔内(Injections, Intraperitoneal);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);神经保护药(Neuroprotective Agents);肽碎片(Peptide Fragments);蛋白质结合(Protein Binding);重组融合蛋白质类(Recombinant Fusion Proteins);tat基因产物, 人免疫缺陷病毒(tat Gene Products, Human Immunodeficiency Virus)

DOI 10.1038/srep20949

PMID 26864599

发布时间 2018-11-13

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Tackling amyloidogenesis in Alzheimer's disease with A2V variants of Amyloid-β.

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Tackling amyloidogenesis in Alzheimer's disease with A2V variants of Amyloid-β.

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