Nutlin-3 treatment spares cisplatin-induced inhibition of bone healing while maintaining osteosarcoma toxicity.

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第一作者： Kimo C,Stine

第一单位： Departments of Pediatrics, University of Arkansas for Medical Sciences, Arkansas.

作者： Kimo C,Stine ^[1] ; Elizabeth C,Wahl ^[2] ; Lichu,Liu ^[2] ; Robert A,Skinner ^[3] ; Jaclyn,VanderSchilden ^[3] ; Robert C,Bunn ^[1] ; Corey O,Montgomery ^[3] ; James,Aronson ^[4] ; David L,Becton ^[1] ; Richard W,Nicholas ^[3] ; Christopher J,Swearingen ^[5] ; Larry J,Suva ^[3] ; Charles K,Lumpkin ^[6]

作者单位： Departments of Pediatrics, University of Arkansas for Medical Sciences, Arkansas. ^[1] Laboratory for Limb Regeneration Research, Arkansas Children's Hospital Research Institute, Arkansas. ^[2] Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas. ^[3] Departments of Pediatrics, University of Arkansas for Medical Sciences, Arkansas.;Laboratory for Limb Regeneration Research, Arkansas Children's Hospital Research Institute, Arkansas.;Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas. ^[4] Departments of Pediatrics, University of Arkansas for Medical Sciences, Arkansas.;Pediatric Biostatistics, Arkansas Children's Hospital Research Institute, Arkansas. ^[5] Departments of Pediatrics, University of Arkansas for Medical Sciences, Arkansas. lumpkincharlesk@uams.edu.;Laboratory for Limb Regeneration Research, Arkansas Children's Hospital Research Institute, Arkansas. lumpkincharlesk@uams.edu. ^[6]

关键词 chemotherapy cisplatin distraction osteogenesis limb salvage nutlin-3