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首页> Brain research bulletin> Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity.

Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity.

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作者： Changwei,Zhou ^[1] ; Rong,Sun ^[2] ; Sujuan,Zhuang ^[3] ; Chongyi,Sun ^[1] ; Yongqing,Jiang ^[1] ; Yang,Cui ^[1] ; Shitou,Li ^[1] ; Yanqiu,Xiao ^[1] ; Yansheng,Du ^[4] ; Huiying,Gu ^[5] ; Qingpeng,Liu ^[6]

作者单位： Department of Orthopedic Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China. ^[1] Department of Outpatient OR, The 1st Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China. ^[2] Department of Acupuncture, Linyi People's Hospital, Linyi 276000, PR China. ^[3] Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA. ^[4] Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: huiygu@iupui.edu. ^[5] Department of Orthopedic Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, PR China. Electronic address: liu@21cn.com. ^[6]

关键词 Cerebellar granule neurons Excitotoxicity Glutamate MAPK Metformin Neuroprotection

主题词动物(Animals);动物, 新生(Animals, Newborn);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);细胞, 培养的(Cells, Cultured);小脑(Cerebellum);细胞色素c类(Cytochromes c);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物相互作用(Drug Interactions);兴奋性氨基酸激动剂(Excitatory Amino Acid Agonists);谷氨酸(Glutamic Acid);MAP激酶激酶4(MAP Kinase Kinase 4);MAP激酶信号系统(MAP Kinase Signaling System);男(雄)性(Male);二甲双胍(Metformin);神经元(Neurons);神经保护药(Neuroprotective Agents);大鼠(Rats)

DOI 10.1016/j.brainresbull.2016.02.009

PMID 26876755

发布时间 2016-12-30

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Brain research bulletin

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