Manipulation of Interleukin-1β and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence.

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第一作者： Dmitry,Ratner

第一单位： From the Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605.

作者： Dmitry,Ratner ^[1] ; M Pontus A,Orning ^[2] ; Kristian K,Starheim ^[2] ; Robyn,Marty-Roix ^[1] ; Megan K,Proulx ^[3] ; Jon D,Goguen ^[3] ; Egil,Lien ^[4]

作者单位： From the Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605. ^[1] From the Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, the Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway, and. ^[2] the Department of Microbiology and Physiological Systems, University of Massachusetts, Worcester, Massachusetts 01655. ^[3] From the Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, the Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway, and egil.lien@umassmed.edu. ^[4]

关键词 Yersinia pestis YopJ YopM caspase 1 (CASP1)cell death inflammasome interleukin 1 (IL-1)interleukin-18 (IL-18)macrophage type III secretion system (T3SS)