Multi-stage inhibition in breast cancer metastasis by orally active triple conjugate, LHTD4 (low molecular weight heparin-taurocholate-tetrameric deoxycholate).

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作者： Farzana,Alam ^[1] ; Taslim A,Al-Hilal ^[2] ; Jooho,Park ^[3] ; Jeong Uk,Choi ^[3] ; Foyez,Mahmud ^[1] ; Jee-Heon,Jeong ^[4] ; In-San,Kim ^[2] ; Sang Yoon,Kim ^[5] ; Seung Rim,Hwang ^[6] ; Youngro,Byun ^[7]

作者单位： Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Pharmacy, Seoul National University, Seoul, South Korea. ^[1] Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, South Korea. ^[2] Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea. ^[3] College of Pharmacy, Yeungnam University, Gyeongsan, South Korea. ^[4] Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, South Korea; Asan Medical Center, Department of Otolaryngology, College of Medicine, University of Ulsan, Seoul, South Korea. ^[5] College of Pharmacy, Chosun University, Gwangju, South Korea. Electronic address: srhwang@chosun.ac.kr. ^[6] Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Pharmacy, Seoul National University, Seoul, South Korea; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea. Electronic address: yrbyun@snu.ac.kr. ^[7]

关键词 CXCL12 Low molecular weight heparin Metastasis Multi-stage targeting Polymeric bile acid TGF-β1