Calcific Aortic Valve Disease: Part 1--Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks.
作者:
关键词
Aortic transvalvular pressure gradientAortic valve inflammation, fibrosis and calcific nodule buildupAortic valvular stenosis (AVS)Bicuspid aortic valve disease (BAVD)Compensatory myocardial hypertrophy in pressure overload (PO)Feedback control of myocardial hypertrophyFetal type genesGenomics of calcific aortic valve disease (CAVD)HemodynamicsImmediate early-response genes (IEGs)Intrinsic component of the total systolic ventricular loadMacromolecular crowding and cardiomyocyte diameters in PO hypertrophyPressure loss recoveryReplication of cardiomyocyte sarcomeres in-parallel and in-series
主题词
动物(Animals);主动脉瓣(Aortic Valve);主动脉瓣狭窄(Aortic Valve Stenosis);钙质沉着症(Calcinosis);反馈, 生理(Feedback, Physiological);疾病遗传易感性(Genetic Predisposition to Disease);血流动力学(Hemodynamics);人类(Humans);动力传导, 细胞(Mechanotransduction, Cellular);表型(Phenotype);试验预期值(Predictive Value of Tests);预后(Prognosis);危险因素(Risk Factors);心室功能, 左(Ventricular Function, Left)
DOI
10.1007/s12265-016-9679-z
PMID
26891845
发布时间
2018-11-13
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