换一批Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide).
第一作者：
Raju,Subramanian
第一单位：
Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.) rajus@amgen.com.
作者：
医学主题词
动物(Animals);生物转化(Biotransformation);钙模拟剂(Calcimimetic Agents);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);狗(Dogs);药物相互作用(Drug Interactions);女(雌)性(Female);HEK293细胞(HEK293 Cells);人类(Humans);肾(Kidney);肝(Liver);男(雄)性(Male);膜转运蛋白质类(Membrane Transport Proteins);分子结构(Molecular Structure);肽类(Peptides);蛋白质结合(Protein Binding);大鼠, 近交BN(Rats, Inbred BN);受体, 钙敏感(Receptors, Calcium-Sensing);危险性评估(Risk Assessment);血清白蛋白(Serum Albumin);构效关系(Structure-Activity Relationship);组织分布(Tissue Distribution);转染(Transfection)
DOI
10.1124/dmd.115.068007
PMID
26895981
发布时间
2025-02-12
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