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首页> Colloids and surfaces. B, Biointerfaces> Enhancing in vitro dissolution and in vivo bioavailability of fenofibrate by solid self-emulsifying matrix combined with SBA-15 mesoporous silica.

Enhancing in vitro dissolution and in vivo bioavailability of fenofibrate by solid self-emulsifying matrix combined with SBA-15 mesoporous silica.

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作者： Guilan,Quan ^[1] ; Qiaoli,Wu ^[2] ; Xiaoxu,Zhang ^[2] ; Zhengwen,Zhan ^[2] ; Chan,Zhou ^[2] ; Bao,Chen ^[2] ; Zhengzan,Zhang ^[2] ; Ge,Li ^[3] ; Xin,Pan ^[4] ; Chuanbin,Wu ^[5]

作者单位： School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou 510006, PR China. ^[1] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. ^[2] Guangzhou Neworld Pharmaceutical Ltd., Co., Guangzhou 510006, PR China. ^[3] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address: pxin_1385@163.com. ^[4] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address: chuanbin_wu@126.com. ^[5]

关键词 Bioavailability Fenofibrate Mesoporous silica Poorly water-soluble drug Self-emulsifying drug delivery system

主题词投药, 口服(Administration, Oral);动物(Animals);曲线下面积(Area Under Curve);生物利用度(Biological Availability);狗(Dogs);乳化剂(Emulsifying Agents);乳状剂(Emulsions);非诺贝特(Fenofibrate);降血脂药物(Hypolipidemic Agents);代谢清除率(Metabolic Clearance Rate);显微镜检查, 电子, 扫描(Microscopy, Electron, Scanning);多孔性(Porosity);二氧化硅(Silicon Dioxide);X线衍射(X-Ray Diffraction)

DOI 10.1016/j.colsurfb.2016.02.013

PMID 26896653

发布时间 2022-03-18

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Colloids and surfaces. B, Biointerfaces

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