Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.
第一作者:
Cefan,Zhou
第一单位:
Membrane Protein Disease and Cancer Research Center, Provincial Cooperative Innovation Center of Industrial Fermentation, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, 430068, China.
作者:
医学主题词
成年人(Adult);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);DNA结合蛋白质类(DNA-Binding Proteins);疾病恶化(Disease Progression);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);神经胶质瘤(Glioma);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);组蛋白类(Histones);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);男(雄)性(Male);中年人(Middle Aged);髓淋巴细胞性白血病蛋白质(Myeloid-Lymphoid Leukemia Protein);肿瘤蛋白质类(Neoplasm Proteins);核蛋白质类(Nuclear Proteins);预后(Prognosis);启动区, 遗传(Promoter Regions, Genetic);原癌基因蛋白质类(Proto-Oncogene Proteins);RNA, 小分子干扰(RNA, Small Interfering);存活率分析(Survival Analysis);转录因子(Transcription Factors);转录激活(Transcriptional Activation);Wnt蛋白质类(Wnt Proteins);β连环素(beta Catenin)
DOI
10.1038/srep22066
PMID
26902498
发布时间
2019-08-16
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Scientific reports
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