作者:
Peter,Bailey [1]
;
David K,Chang [2]
;
Katia,Nones [2]
;
Amber L,Johns [3]
;
Ann-Marie,Patch [4]
;
Marie-Claude,Gingras [5]
;
David K,Miller [1]
;
Angelika N,Christ [6]
;
Tim J C,Bruxner [3]
;
Michael C,Quinn [1]
;
Craig,Nourse [6]
;
L Charles,Murtaugh [7]
;
Ivon,Harliwong [8]
;
Senel,Idrisoglu [9]
;
Suzanne,Manning [1]
;
Ehsan,Nourbakhsh [3]
;
Shivangi,Wani [1]
;
Lynn,Fink [1]
;
Oliver,Holmes [1]
;
Venessa,Chin [6]
;
Matthew J,Anderson [1]
;
Stephen,Kazakoff [2]
;
Conrad,Leonard [10]
;
Felicity,Newell [1]
;
Nick,Waddell [1]
;
Scott,Wood [1]
;
Qinying,Xu [1]
;
Peter J,Wilson [1]
;
Nicole,Cloonan [6]
;
Karin S,Kassahn [1]
;
Darrin,Taylor [1]
;
Kelly,Quek [6]
;
Alan,Robertson [3]
;
Lorena,Pantano [1]
;
Laura,Mincarelli [1]
;
Luis N,Sanchez [6]
;
Lisa,Evers [1]
;
Jianmin,Wu [6]
;
Mark,Pinese [1]
;
Mark J,Cowley [1]
;
Marc D,Jones [1]
;
Emily K,Colvin [6]
;
Adnan M,Nagrial [1]
;
Emily S,Humphrey [6]
;
Lorraine A,Chantrill [1]
;
Amanda,Mawson [1]
;
Jeremy,Humphris [6]
;
Angela,Chou [1]
;
Marina,Pajic [11]
;
Christopher J,Scarlett [12]
;
Andreia V,Pinho [1]
;
Marc,Giry-Laterriere [1]
;
Ilse,Rooman [1]
;
Jaswinder S,Samra [13]
;
James G,Kench [2]
;
Jessica A,Lovell [2]
;
Neil D,Merrett [2]
;
Christopher W,Toon [3]
;
Krishna,Epari [3]
;
Nam Q,Nguyen [3]
;
Andrew,Barbour [2]
;
Nikolajs,Zeps [3]
;
Kim,Moran-Jones [3]
;
Nigel B,Jamieson [3]
;
Janet S,Graham [3]
;
Fraser,Duthie [3]
;
Karin,Oien [14]
;
Jane,Hair [3]
;
Robert,Grützmann [3]
;
Anirban,Maitra [3]
;
Christine A,Iacobuzio-Donahue [15]
;
Christopher L,Wolfgang [3]
;
Richard A,Morgan [16]
;
Rita T,Lawlor [3]
;
Vincenzo,Corbo [17]
;
Claudio,Bassi [3]
;
Borislav,Rusev [3]
;
Paola,Capelli [3]
;
Roberto,Salvia [18]
;
Giampaolo,Tortora [19]
;
Debabrata,Mukhopadhyay [3]
;
Gloria M,Petersen [19]
;
Australian Pancreatic Cancer Genome Initiative [20]
;
Donna M,Munzy [3]
;
William E,Fisher [5]
;
Saadia A,Karim [21]
;
James R,Eshleman [3]
;
Ralph H,Hruban [22]
;
Christian,Pilarsky [23]
;
Jennifer P,Morton [24]
;
Owen J,Sansom [25]
;
Aldo,Scarpa [2]
;
Elizabeth A,Musgrove [2]
;
Ulla-Maja Hagbo,Bailey [26]
;
Oliver,Hofmann [27]
;
Robert L,Sutherland [2]
;
David A,Wheeler [28]
;
Anthony J,Gill [29]
;
Richard A,Gibbs [3]
;
John V,Pearson [29]
;
Nicola,Waddell [30]
;
Andrew V,Biankin [31]
;
Sean M,Grimmond [32]
作者单位:
Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
[1]
Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.
[2]
The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.
[3]
Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia.
[4]
South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia.
[5]
QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia.
[6]
Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
[7]
Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.
[8]
Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
[9]
Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA.
[10]
Genetic and Molecular Pathology, SA Pathology, Adelaide, South Australia 5000, Australia.
[11]
School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5000, Australia.
[12]
Harvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
[13]
Macarthur Cancer Therapy Centre, Campbelltown Hospital, New South Wales 2560, Australia.
[14]
Department of Pathology. SydPath, St Vincent's Hospital, Sydney, NSW 2010, Australia.
[15]
St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2052, Australia.
[16]
School of Environmental &Life Sciences, University of Newcastle, Ourimbah, New South Wales 2258, Australia.
[17]
Department of Surgery, Royal North Shore Hospital, St Leonards, Sydney, New South Wales 2065, Australia.
[18]
University of Sydney, Sydney, New South Wales 2006, Australia.
[19]
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown New South Wales 2050, Australia.
[20]
School of Medicine, University of Western Sydney, Penrith, New South Wales 2175, Australia.
[21]
Fiona Stanley Hospital, Robin Warren Drive, Murdoch, Western Australia 6150, Australia.
[22]
Department of Gastroenterology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
[23]
Department of Surgery, Princess Alexandra Hospital, Ipswich Rd, Woollongabba, Queensland 4102, Australia.
[24]
School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia and St John of God Pathology, 12 Salvado Rd, Subiaco, Western Australia 6008, Australia.
[25]
Academic Unit of Surgery, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow G4 OSF, UK.
[26]
West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow G31 2ER, UK.
[27]
Department of Medical Oncology, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK.
[28]
Department of Pathology, Southern General Hospital, Greater Glasgow &Clyde NHS, Glasgow G51 4TF, UK.
[29]
GGC Bio-repository, Pathology Department, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TY, UK.
[30]
Department of Surgery, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
[31]
Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston Texas 77030, USA.
[32]
The David M. Rubenstein Pancreatic Cancer Research Center and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
[33]
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
[34]
Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
[35]
ARC-Net Applied Research on Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy.
[36]
Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy.
[37]
Department of Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy.
[38]
Department of Medical Oncology, Comprehensive Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy.
[39]
Mayo Clinic, Rochester, Minnesota 55905, USA.
[40]
Elkins Pancreas Center, Baylor College of Medicine, One Baylor Plaza, MS226, Houston, Texas 77030-3411, USA.
[41]
Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.
[42]
Institute for Cancer Science, University of Glasgow, Glasgow G12 8QQ, UK.
[43]
University of Melbourne, Parkville, Victoria 3010, Australia.
[44]
主题词
动物(Animals);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞系, 肿瘤(Cell Line, Tumor);DNA甲基化(DNA Methylation);DNA结合蛋白质类(DNA-Binding Proteins);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因调控网络(Gene Regulatory Networks);基因, 肿瘤(Genes, Neoplasm);基因组, 人(Genome, Human);基因组学(Genomics);肝细胞核因子3β(Hepatocyte Nuclear Factor 3-beta);肝细胞核因子3γ(Hepatocyte Nuclear Factor 3-gamma);组蛋白脱甲基酶类(Histone Demethylases);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);小鼠(Mice);突变(Mutation);核蛋白质类(Nuclear Proteins);胰腺肿瘤(Pancreatic Neoplasms);预后(Prognosis);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);存活率分析(Survival Analysis);反式激活因子类(Trans-Activators);转录因子(Transcription Factors);转录, 遗传(Transcription, Genetic);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);肿瘤抑制蛋白质类(Tumor Suppressor Proteins);斑马鱼蛋白质类(Zebrafish Proteins)
DOI
10.1038/nature16965
PMID
26909576
发布时间
2024-02-10
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Nature
Nature
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