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Genomic analyses identify molecular subtypes of pancreatic cancer.

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作者: Peter,Bailey [1] ; David K,Chang [2] ; Katia,Nones [2] ; Amber L,Johns [3] ; Ann-Marie,Patch [4] ; Marie-Claude,Gingras [5] ; David K,Miller [1] ; Angelika N,Christ [6] ; Tim J C,Bruxner [3] ; Michael C,Quinn [1] ; Craig,Nourse [6] ; L Charles,Murtaugh [7] ; Ivon,Harliwong [8] ; Senel,Idrisoglu [9] ; Suzanne,Manning [1] ; Ehsan,Nourbakhsh [3] ; Shivangi,Wani [1] ; Lynn,Fink [1] ; Oliver,Holmes [1] ; Venessa,Chin [6] ; Matthew J,Anderson [1] ; Stephen,Kazakoff [2] ; Conrad,Leonard [10] ; Felicity,Newell [1] ; Nick,Waddell [1] ; Scott,Wood [1] ; Qinying,Xu [1] ; Peter J,Wilson [1] ; Nicole,Cloonan [6] ; Karin S,Kassahn [1] ; Darrin,Taylor [1] ; Kelly,Quek [6] ; Alan,Robertson [3] ; Lorena,Pantano [1] ; Laura,Mincarelli [1] ; Luis N,Sanchez [6] ; Lisa,Evers [1] ; Jianmin,Wu [6] ; Mark,Pinese [1] ; Mark J,Cowley [1] ; Marc D,Jones [1] ; Emily K,Colvin [6] ; Adnan M,Nagrial [1] ; Emily S,Humphrey [6] ; Lorraine A,Chantrill [1] ; Amanda,Mawson [1] ; Jeremy,Humphris [6] ; Angela,Chou [1] ; Marina,Pajic [11] ; Christopher J,Scarlett [12] ; Andreia V,Pinho [1] ; Marc,Giry-Laterriere [1] ; Ilse,Rooman [1] ; Jaswinder S,Samra [13] ; James G,Kench [2] ; Jessica A,Lovell [2] ; Neil D,Merrett [2] ; Christopher W,Toon [3] ; Krishna,Epari [3] ; Nam Q,Nguyen [3] ; Andrew,Barbour [2] ; Nikolajs,Zeps [3] ; Kim,Moran-Jones [3] ; Nigel B,Jamieson [3] ; Janet S,Graham [3] ; Fraser,Duthie [3] ; Karin,Oien [14] ; Jane,Hair [3] ; Robert,Grützmann [3] ; Anirban,Maitra [3] ; Christine A,Iacobuzio-Donahue [15] ; Christopher L,Wolfgang [3] ; Richard A,Morgan [16] ; Rita T,Lawlor [3] ; Vincenzo,Corbo [17] ; Claudio,Bassi [3] ; Borislav,Rusev [3] ; Paola,Capelli [3] ; Roberto,Salvia [18] ; Giampaolo,Tortora [19] ; Debabrata,Mukhopadhyay [3] ; Gloria M,Petersen [19] ; Australian Pancreatic Cancer Genome Initiative [20] ; Donna M,Munzy [3] ; William E,Fisher [5] ; Saadia A,Karim [21] ; James R,Eshleman [3] ; Ralph H,Hruban [22] ; Christian,Pilarsky [23] ; Jennifer P,Morton [24] ; Owen J,Sansom [25] ; Aldo,Scarpa [2] ; Elizabeth A,Musgrove [2] ; Ulla-Maja Hagbo,Bailey [26] ; Oliver,Hofmann [27] ; Robert L,Sutherland [2] ; David A,Wheeler [28] ; Anthony J,Gill [29] ; Richard A,Gibbs [3] ; John V,Pearson [29] ; Nicola,Waddell [30] ; Andrew V,Biankin [31] ; Sean M,Grimmond [32]
作者单位: Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia. [1] Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK. [2] The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia. [3] Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia. [4] South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia. [5] QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia. [6] Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA. [7] Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA. [8] Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA. [9] Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA. [10] Genetic and Molecular Pathology, SA Pathology, Adelaide, South Australia 5000, Australia. [11] School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5000, Australia. [12] Harvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA. [13] Macarthur Cancer Therapy Centre, Campbelltown Hospital, New South Wales 2560, Australia. [14] Department of Pathology. SydPath, St Vincent's Hospital, Sydney, NSW 2010, Australia. [15] St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2052, Australia. [16] School of Environmental &Life Sciences, University of Newcastle, Ourimbah, New South Wales 2258, Australia. [17] Department of Surgery, Royal North Shore Hospital, St Leonards, Sydney, New South Wales 2065, Australia. [18] University of Sydney, Sydney, New South Wales 2006, Australia. [19] Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown New South Wales 2050, Australia. [20] School of Medicine, University of Western Sydney, Penrith, New South Wales 2175, Australia. [21] Fiona Stanley Hospital, Robin Warren Drive, Murdoch, Western Australia 6150, Australia. [22] Department of Gastroenterology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. [23] Department of Surgery, Princess Alexandra Hospital, Ipswich Rd, Woollongabba, Queensland 4102, Australia. [24] School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia and St John of God Pathology, 12 Salvado Rd, Subiaco, Western Australia 6008, Australia. [25] Academic Unit of Surgery, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow G4 OSF, UK. [26] West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow G31 2ER, UK. [27] Department of Medical Oncology, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK. [28] Department of Pathology, Southern General Hospital, Greater Glasgow &Clyde NHS, Glasgow G51 4TF, UK. [29] GGC Bio-repository, Pathology Department, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TY, UK. [30] Department of Surgery, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany. [31] Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston Texas 77030, USA. [32] The David M. Rubenstein Pancreatic Cancer Research Center and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. [33] Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. [34] Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. [35] ARC-Net Applied Research on Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy. [36] Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy. [37] Department of Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy. [38] Department of Medical Oncology, Comprehensive Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy. [39] Mayo Clinic, Rochester, Minnesota 55905, USA. [40] Elkins Pancreas Center, Baylor College of Medicine, One Baylor Plaza, MS226, Houston, Texas 77030-3411, USA. [41] Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK. [42] Institute for Cancer Science, University of Glasgow, Glasgow G12 8QQ, UK. [43] University of Melbourne, Parkville, Victoria 3010, Australia. [44]
DOI 10.1038/nature16965
PMID 26909576
发布时间 2024-02-10
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