Determining the isotopic abundance of a labeled compound by mass spectrometry and how correcting for natural abundance distribution using analogous data from the unlabeled compound leads to a systematic error.

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作者： David J,Schenk ^[1] ; William J S,Lockley ^[2] ; Charles S,Elmore ^[3] ; Dave,Hesk ^[1] ; Drew,Roberts ^[4]

作者单位： Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ, USA. ^[1] Department of Chemistry, University of Surrey, Guildford, Surrey, UK. ^[2] Isotope Chemistry, DMPK, Drug Safety and Metabolism, AstraZeneca, Mölndal, Sweden. ^[3] High Performance Computing, Informatics IT (Rahway), Merck & Co., Inc., Rahway, NJ, USA. ^[4]

关键词 IsoCor IsoPat2 LC/MS Pynac carbon-13 carbon-14 isotopic distribution mass spectrometry measurement error natural abundance natural abundance skew nitrogen-15 specific activity

主题词碳同位素(Carbon Isotopes);同位素标记(Isotope Labeling);质谱分析法(Mass Spectrometry);研究设计(Research Design);缬氨酸(Valine)

DOI 10.1002/jlcr.3370

PMID 26916110

发布时间 2017-01-04

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