Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
第一作者:
Matthew,Volgraf
第一单位:
Pharmaron-Beijing Co. Ltd. , 6 Taihe Road, BDA, Beijing 100176, PR China.
作者:
医学主题词
动物(Animals);CHO细胞(CHO Cells);钙(Calcium);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);结晶学, X线(Crystallography, X-Ray);药物发现(Drug Discovery);兴奋性氨基酸拮抗剂(Excitatory Amino Acid Antagonists);HEK293细胞(HEK293 Cells);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);动力学(Kinetics);模型, 分子(Models, Molecular);膜片钳术(Patch-Clamp Techniques);受体, AMPA(Receptors, AMPA);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);构效关系(Structure-Activity Relationship)
DOI
10.1021/acs.jmedchem.5b02010
PMID
26919761
发布时间
2018-12-02
- 浏览7
Journal of medicinal chemistry
2760-79页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文


换一批



