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Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.

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第一作者： Kohsuke,Kanekura

第一单位： Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Department of Molecular Pathology, Tokyo Medical University, Tokyo 160-8402, Japan and.

作者： Kohsuke,Kanekura ^[1] ; Takuya,Yagi ^[2] ; Alexander J,Cammack ^[3] ; Jana,Mahadevan ^[2] ; Masahiko,Kuroda ^[4] ; Matthew B,Harms ^[5] ; Timothy M,Miller ^[3] ; Fumihiko,Urano ^[6]

作者单位： Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Department of Molecular Pathology, Tokyo Medical University, Tokyo 160-8402, Japan and. ^[1] Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research. ^[2] Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA. ^[3] Department of Molecular Pathology, Tokyo Medical University, Tokyo 160-8402, Japan and. ^[4] Department of Neurology, Columbia University College of Physicians and Surgeon, New York, NY 10032, USA. ^[5] Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Department of Pathology and Immunology and urano@dom.wustl.edu. ^[6]

医学主题词肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);动物(Animals);脑(Brain);病例对照研究(Case-Control Studies);细胞, 培养的(Cells, Cultured);DNA重复序列扩增(DNA Repeat Expansion);二肽类(Dipeptides);核不均一核糖核蛋白A-B组(Heterogeneous-Nuclear Ribonucleoprotein Group A-B);人类(Humans);小鼠(Mice);运动神经元(Motor Neurons);蛋白质生物合成(Protein Biosynthesis);蛋白质类(Proteins)

DOI 10.1093/hmg/ddw052

PMID 26931465

发布时间 2023-07-24

基金项目

P30 DK020579/DK/NIDDK NIH HHS/United States P60 DK020579/DK/NIDDK NIH HHS/United States T32 GM008151/GM/NIGMS NIH HHS/United States UL1 TR000448/TR/NCATS NIH HHS/United States

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