Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy.

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第一作者： A-Rum,Yoon

第一单位： a Department of Bioengineering, College of Engineering , Hanyang University , Seoul , Korea.

作者： A-Rum,Yoon ^[1] ; Jinwoo,Hong ^[1] ; Sung Wan,Kim ^[1] ; Chae-Ok,Yun ^[2]

作者单位： a Department of Bioengineering, College of Engineering , Hanyang University , Seoul , Korea. ^[1] b Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry , University of Utah , Salt Lake City , UT , USA. ^[2]

关键词 Adenovirus active targeting chimeric fiber enhanced permeability and retention effect external stimuli-induced targeting fiber modification minor capsid protein nanomaterial oncolytic adenovirus passive targeting polymer targeting moiety tumor microenvironment-responsive delivery

主题词腺病毒科(Adenoviridae);遗传载体(Genetic Vectors);人类(Humans);肿瘤(Neoplasms);向性(Tropism)

DOI 10.1517/17425247.2016.1158707

PMID 26967319

发布时间 2018-12-02

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