Pharmacological characterization of EN-9, a novel chimeric peptide of endomorphin-2 and neuropeptide FF that produces potent antinociceptive activity and limited tolerance.
作者:
关键词
AntinociceptionChimeric peptideEndomorphin-2IBMX (PubChem CID: 3758)NPFF (PubChem CID: 123797)Neuropeptide FFNon-toleranceOpioidRF9 (PubChem CID: 53320361)beta-Funaltrexamine (PubChem CID: 5311018)endomorphin-2 (PubChem CID: 5311081)forskolin (PubChem CID: 47936)morphine (PubChem CID: 5288826)naloxone (PubChem CID: 5464092)naltrindole (PubChem CID: 5497186)nor-binaltorphimine (PubChem CID: 5480230)
主题词
镇痛药(Analgesics);镇痛药, 阿片类(Analgesics, Opioid);动物(Animals);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物耐受性(Drug Tolerance);HEK293细胞(HEK293 Cells);人类(Humans);注射, 脑室内(Injections, Intraventricular);男(雄)性(Male);小鼠(Mice);寡肽类(Oligopeptides);疼痛测定(Pain Measurement);肽碎片(Peptide Fragments);肽类(Peptides);受体, 神经肽(Receptors, Neuropeptide);受体, 阿片样, κ(Receptors, Opioid, kappa)
DOI
10.1016/j.neuropharm.2016.03.017
PMID
26970017
发布时间
2018-02-07
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Neuropharmacology
364-72页
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