Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer's disease.

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作者： Claudio,Liguori ^[1] ; Marzia,Nuccetelli ^[2] ; Francesca,Izzi ^[3] ; Giuseppe,Sancesario ^[4] ; Andrea,Romigi ^[3] ; Alessandro,Martorana ^[5] ; Chiara,Amoroso ^[3] ; Sergio,Bernardini ^[2] ; Maria Grazia,Marciani ^[5] ; Nicola Biagio,Mercuri ^[6] ; Fabio,Placidi ^[3]

作者单位： Sleep Medicine Centre, Neurophysiopathology Unit, Department of Systems Medicine, "Tor Vergata" University of Rome, Rome, Italy. Electronic address: dott.claudioliguori@yahoo.it. ^[1] Clinical Biochemistry and Molecular Biology, "Tor Vergata" University of Rome, Rome, Italy. ^[2] Sleep Medicine Centre, Neurophysiopathology Unit, Department of Systems Medicine, "Tor Vergata" University of Rome, Rome, Italy. ^[3] Neurology Unit, Department of Systems Medicine, "Tor Vergata" University of Rome, Rome, Italy; Fondazione Santa Lucia IRCCS, Rome, Italy. ^[4] Neurology Unit, Department of Systems Medicine, "Tor Vergata" University of Rome, Rome, Italy. ^[5] Sleep Medicine Centre, Neurophysiopathology Unit, Department of Systems Medicine, "Tor Vergata" University of Rome, Rome, Italy; Fondazione Santa Lucia IRCCS, Rome, Italy. ^[6]

关键词 Mild cognitive impairment due to Alzheimer's disease Orexin Polysomnography REM sleep disruption Subjective sleep disturbances