Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice.

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作者： Yasuharu,Watanabe ^[1] ; Yoshinori,Nagai ^[1] ; Hiroe,Honda ^[2] ; Naoki,Okamoto ^[1] ; Seiji,Yamamoto ^[3] ; Takeru,Hamashima ^[1] ; Yoko,Ishii ^[4] ; Miyako,Tanaka ^[4] ; Takayoshi,Suganami ^[4] ; Masakiyo,Sasahara ^[5] ; Kensuke,Miyake ^[2] ; Kiyoshi,Takatsu ^[5]

作者单位： Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, JAPAN. ^[1] JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, JAPAN. ^[2] Toyama Prefectural Institute for Pharmaceutical Research, 17-1 Nakataikouyama, Imizu City, Toyama 939-0363, JAPAN. ^[3] Department of Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, JAPAN. ^[4] Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, JAPAN. ^[5] Division of Infectious Genetics, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, JAPAN. ^[6] Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, JAPAN. ^[7]

主题词脂细胞(Adipocytes);脂肪组织, 白色(Adipose Tissue, White);动物(Animals);消炎药(Anti-Inflammatory Agents);细胞分化(Cell Differentiation);查耳酮类(Chalcones);共同培养技术(Coculture Techniques);纤维化(Fibrosis);免疫, 先天(Immunity, Innate);炎性体(Inflammasomes);炎症(Inflammation);干扰素γ(Interferon-gamma);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);NF-κB(NF-kappa B);旁分泌细胞细胞间通讯(Paracrine Communication);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1038/srep23097

PMID 26975571

发布时间 2018-11-13

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Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice.

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Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice.

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