An extended set of yeast-based functional assays accurately identifies human disease mutations.

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作者： Song,Sun ^[1] ; Fan,Yang ^[2] ; Guihong,Tan ^[3] ; Michael,Costanzo ^[3] ; Rose,Oughtred ^[4] ; Jodi,Hirschman ^[4] ; Chandra L,Theesfeld ^[4] ; Pritpal,Bansal ^[2] ; Nidhi,Sahni ^[5] ; Song,Yi ^[5] ; Analyn,Yu ^[2] ; Tanya,Tyagi ^[2] ; Cathy,Tie ^[6] ; David E,Hill ^[5] ; Marc,Vidal ^[5] ; Brenda J,Andrews ^[3] ; Charles,Boone ^[3] ; Kara,Dolinski ^[4] ; Frederick P,Roth ^[7]

作者单位： Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; Department of Medical Biochemistry and Microbiology, Uppsala University, SE-75123 Uppsala, Sweden; ^[1] Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; ^[2] Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; ^[3] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA; ^[4] Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; ^[5] Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; ^[6] Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; Canadian Institute for Advanced Research, Toronto, Ontario, M5G 1Z8, Canada. ^[7]

主题词遗传互补测验(Genetic Complementation Test);遗传性疾病, 先天性(Genetic Diseases, Inborn);人类(Humans);酿酒酵母菌(Saccharomyces cerevisiae);转录, 遗传(Transcription, Genetic)

DOI 10.1101/gr.192526.115

PMID 26975778

发布时间 2019-01-11

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准确一般字义偏差语意偏离译文作用小提交