The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-).-论文-万方医学网

第一作者： Kenji,Tsuchihashi

第一单位： Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan.

作者： Kenji,Tsuchihashi ^[1] ; Shogo,Okazaki ^[2] ; Mitsuyo,Ohmura ^[3] ; Miyuki,Ishikawa ^[2] ; Oltea,Sampetrean ^[2] ; Nobuyuki,Onishi ^[2] ; Hiroaki,Wakimoto ^[4] ; Momoko,Yoshikawa ^[2] ; Ryo,Seishima ^[2] ; Yoshimi,Iwasaki ^[2] ; Takayuki,Morikawa ^[5] ; Shinya,Abe ^[6] ; Ayumi,Takao ^[6] ; Misato,Shimizu ^[6] ; Takashi,Masuko ^[6] ; Motoo,Nagane ^[7] ; Frank B,Furnari ^[8] ; Tetsu,Akiyama ^[9] ; Makoto,Suematsu ^[3] ; Eishi,Baba ^[10] ; Koichi,Akashi ^[10] ; Hideyuki,Saya ^[2] ; Osamu,Nagano ^[11]

作者单位： Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan. ^[1] Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. ^[2] Department of Biochemistry, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO), Suematsu Gas Biology Project, Tokyo, Japan. ^[3] Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. ^[4] Department of Biochemistry, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. ^[5] Cell Biology Laboratory, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kinki University, Higashiosaka, Osaka, Japan. ^[6] Department of Neurosurgery, Kyorin University Faculty of Medicine, Mitaka, Tokyo, Japan. ^[7] Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California. ^[8] Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. ^[9] Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan. ^[10] Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan. osmna@sb3.so-net.ne.jp. ^[11]

主题词氨基酸转运系统y+(Amino Acid Transport System y+);动物(Animals);抗氧化剂(Antioxidants);细胞凋亡(Apoptosis);脑肿瘤(Brain Neoplasms);细胞膜(Cell Membrane);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);胱氨酸(Cystine);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);神经胶质瘤(Glioma);谷氨酸(Glutamic Acid);人类(Humans);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, 裸(Mice, Nude);小鼠, SCID(Mice, SCID);活性氧(Reactive Oxygen Species);柳氮磺胺吡啶(Sulfasalazine);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/0008-5472.CAN-15-2121

PMID 26980765

发布时间 2022-03-10

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The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-).

Cancer research

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The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-).

Cancer research

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Cancer research

相关期刊

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