Antitumour activity of the glycoengineered type II anti-CD20 antibody obinutuzumab (GA101) in combination with the MDM2-selective antagonist idasanutlin (RG7388).
第一作者:
Frank,Herting
第一单位:
Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Munich, Germany.
作者:
医学主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);杀伤细胞, 天然(Killer Cells, Natural);淋巴细胞去除术(Lymphocyte Depletion);淋巴瘤, B细胞(Lymphoma, B-Cell);小鼠(Mice);原癌基因蛋白质c-mdm2(Proto-Oncogene Proteins c-mdm2);吡咯烷类(Pyrrolidines);肿瘤负荷(Tumor Burden);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1111/ejh.12756
PMID
26993060
发布时间
2017-02-06
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