HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.-论文-万方医学网

作者： Niek G J,Leus ^[1] ; Petra E,van der Wouden ^[1] ; Thea,van den Bosch ^[1] ; Wouter T R,Hooghiemstra ^[1] ; Maria E,Ourailidou ^[1] ; Loes E M,Kistemaker ^[2] ; Rainer,Bischoff ^[3] ; Reinoud,Gosens ^[2] ; Hidde J,Haisma ^[1] ; Frank J,Dekker ^[4]

作者单位： Department of Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. ^[1] Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. ^[2] Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. ^[3] Department of Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address: f.j.dekker@rug.nl. ^[4]

主题词乙酰化作用(Acetylation);丙烯酰胺类(Acrylamides);动物(Animals);消炎药(Anti-Inflammatory Agents);细胞系(Cell Line);基因表达调控(Gene Expression Regulation);组蛋白脱乙酰基酶1(Histone Deacetylase 1);组蛋白脱乙酰基酶2(Histone Deacetylase 2);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);组蛋白脱乙酰基酶类(Histone Deacetylases);组蛋白类(Histones);人类(Humans);肺(Lung);巨噬细胞(Macrophages);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);肌细胞, 平滑肌(Myocytes, Smooth Muscle);苯二胺类(Phenylenediamines);肺炎(Pneumonia);呼吸道黏膜(Respiratory Mucosa);转录因子RelA(Transcription Factor RelA);转录, 遗传(Transcription, Genetic)

DOI 10.1016/j.bcp.2016.03.010

PMID 26993378

发布时间 2022-01-29

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HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

Biochemical pharmacology

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Biochemical pharmacology

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HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

Biochemical pharmacology

相似文献

Biochemical pharmacology

相关期刊

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