Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans.-论文-万方医学网

第一作者： Lotte C,Houtepen

第一单位： Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.

作者： Lotte C,Houtepen ^[1] ; Christiaan H,Vinkers ^[1] ; Tania,Carrillo-Roa ^[2] ; Marieke,Hiemstra ^[3] ; Pol A,van Lier ^[4] ; Wim,Meeus ^[5] ; Susan,Branje ^[3] ; Christine M,Heim ^[6] ; Charles B,Nemeroff ^[7] ; Jonathan,Mill ^[8] ; Leonard C,Schalkwyk ^[9] ; Menno P,Creyghton ^[10] ; René S,Kahn ^[1] ; Marian,Joëls ^[11] ; Elisabeth B,Binder ^[12] ; Marco P M,Boks ^[1]

作者单位： Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. ^[1] Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany. ^[2] Research Centre Adolescent Development, Department Youth &Family, University Utrecht (UU), Utrecht 3584 CS, The Netherlands. ^[3] Department of Developmental Psychology, VU University, Amsterdam 1081 BT, The Netherlands. ^[4] Research Centre Adolescent Development, Department Youth &Family, University Utrecht (UU), Utrecht 3584 CS, The Netherlands.;Department of Developmental Psychology, Tilburg University 5000 LE, Tilburg, The Netherlands. ^[5] Institute of Medical Psychology, Charité-University Medicine, Medical Centre, 10117 Berlin, Germany.;Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, USA. ^[6] Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, 33136, Florida, USA. ^[7] University of Exeter Medical School, University of Exeter, EX2 5DW, Devon, UK.;Institute of Psychiatry, Psychology &Neuroscience, King's College London, SE5 8AF, London, UK. ^[8] School of Biological Sciences, University of Essex, CO4 3SQ Colchester, UK. ^[9] Hubrecht Institute-KNAW and University Medical Center Utrecht (UMCU), Utrecht 3584CT, The Netherlands. ^[10] Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht (UMCU), Utrecht 3584 CG, The Netherlands. ^[11] Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich 80804, Germany.;Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA. ^[12]

医学主题词青少年(Adolescent);成年人(Adult);年龄因素(Age Factors);老年人(Aged);儿童(Child);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);基因调控网络(Gene Regulatory Networks);基因座(Genetic Loci);基因组, 人(Genome, Human);全基因组关联研究(Genome-Wide Association Study);组蛋白类(Histones);人类(Humans);氢化可的松(Hydrocortisone);男(雄)性(Male);中年人(Middle Aged);模型, 遗传学(Models, Genetic);干细胞因子(Stem Cell Factor);应激, 心理学(Stress, Psychological);创伤和损伤(Wounds and Injuries);青年人(Young Adult)

DOI 10.1038/ncomms10967

PMID 26997371

发布时间 2022-03-30

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Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans.

Nature communications

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Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans.

Nature communications

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Nature communications

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