Effects of Chemical Conjugation of l-Leucine to Chitosan on Dispersibility and Controlled Release of Drug from a Nanoparticulate Dry Powder Inhaler Formulation.

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第一作者： Mohammad D A,Muhsin

第一单位： Institute of Health and Biomedical Innovation, Queensland University of Technology , 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia.;Pharmacy Discipline, Faculty of Health, Queensland University of Technology , Brisbane, Queensland 4000, Australia.

作者： Mohammad D A,Muhsin ^[1] ; Graeme,George ^[2] ; Kenneth,Beagley ^[3] ; Vito,Ferro ^[4] ; Hui,Wang ^[5] ; Nazrul,Islam ^[1]

作者单位： Institute of Health and Biomedical Innovation, Queensland University of Technology , 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia.;Pharmacy Discipline, Faculty of Health, Queensland University of Technology , Brisbane, Queensland 4000, Australia. ^[1] Institute of Health and Biomedical Innovation, Queensland University of Technology , 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia.;School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology , Brisbane, Queensland 4000, Australia. ^[2] Institute of Health and Biomedical Innovation, Queensland University of Technology , 60 Musk Avenue, Kelvin Grove, Brisbane, Queensland 4059, Australia. ^[3] School of Chemistry and Molecular Biosciences, The University of Queensland , Brisbane, Queensland 4072, Australia. ^[4] Pharmacy Discipline, Faculty of Health, Queensland University of Technology , Brisbane, Queensland 4000, Australia. ^[5]

关键词 chitosan controlled release diltiazem hydrochloride dry powder inhaler (DPI)l-leucine nanoparticles pulmonary delivery