Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors.

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作者： Chiara,Foglieni ^[1] ; Katiuscia,Pagano ^[2] ; Marco,Lessi ^[3] ; Antonella,Bugatti ^[4] ; Elisabetta,Moroni ^[5] ; Denise,Pinessi ^[1] ; Andrea,Resovi ^[1] ; Domenico,Ribatti ^[6] ; Sabrina,Bertini ^[7] ; Laura,Ragona ^[2] ; Fabio,Bellina ^[3] ; Marco,Rusnati ^[4] ; Giorgio,Colombo ^[5] ; Giulia,Taraboletti ^[1]

作者单位： Tumor Angiogenesis Unit, Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, 24126 Italy. ^[1] Laboratorio NMR, Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Milano, 20133 Italy. ^[2] Dipartimento di Chimica e Chimica Industriale, Università Di Pisa, Pisa, 56124, Italy. ^[3] Section of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, 25123 Italy. ^[4] Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Milano, 20131 Italy. ^[5] Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, 70121 Italy, and National Cancer Institute "Giovanni Paolo II", Bari, 70124 Italy. ^[6] Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Milano 20133, Italy. ^[7]

主题词血管生成抑制剂(Angiogenesis Inhibitors);计算生物学(Computational Biology);药物发现(Drug Discovery);成纤维细胞生长因子2(Fibroblast Growth Factor 2);人类(Humans);配体(Ligands);磁共振波谱学(Magnetic Resonance Spectroscopy)

DOI 10.1038/srep23432

PMID 27000667

发布时间 2018-11-13

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Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors.

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Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors.

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