Human Helicase RECQL4 Drives Cisplatin Resistance in Gastric Cancer by Activating an AKT-YB1-MDR1 Signaling Pathway.

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作者： Dongliang,Mo ^[1] ; Hongbo,Fang ^[2] ; Kaifeng,Niu ^[1] ; Jing,Liu ^[1] ; Meng,Wu ^[3] ; Shiyou,Li ^[2] ; Tienian,Zhu ^[4] ; Mohammed A,Aleskandarany ^[5] ; Arvind,Arora ^[5] ; Dileep N,Lobo ^[6] ; Srinivasan,Madhusudan ^[5] ; Adayabalam S,Balajee ^[7] ; Zhenfen,Chi ^[8] ; Yongliang,Zhao ^[8]

作者单位： Key Laboratory of Genomic and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. University of Chinese Academy of Sciences, Beijing, China. ^[1] Key Laboratory of Genomic and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. ^[2] Biological Institute, Hebei Academy of Sciences, Shijiazhuang, China. ^[3] Department of Medical Oncology, Bethune International Peace Hospital, Shijiazhuang, China. ^[4] Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham University Hospitals, City Hospital Campus, Nottingham, United Kingdom. ^[5] Gastrointestinal Surgery, National Institute for Health Research Nottingham Digestive Diseases Centre, Biomedical Research Unit, Nottingham University Hospitals and University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom. ^[6] REAC/TS, Oak Ridge Associated Universities, Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee. ^[7] Key Laboratory of Genomic and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. zhaoyongliang@big.ac.cn chizf@big.ac.cn. ^[8]