Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.-论文-万方医学网

作者： Marilena,Colaianna ^[1] ; Sten,Ilmjärv ^[1] ; Hedi,Peterson ^[2] ; Ilse,Kern ^[3] ; Stephanie,Julien ^[4] ; Mathurin,Baquié ^[1] ; Giorgia,Pallocca ^[5] ; Sieto,Bosgra ^[6] ; Agapios,Sachinidis ^[7] ; Jan G,Hengstler ^[8] ; Marcel,Leist ^[9] ; Karl-Heinz,Krause ^[10]

作者单位： Department of Pathology and Immunology, Medical School, University of Geneva, Geneva, Switzerland. ^[1] Quretec Ltd, Ülikooli 6a, Tartu, Estonia. ^[2] Department of Pediatrics, Geneva University Hospital, Geneva, Switzerland. ^[3] Department of Genetic and Laboratory Medicine, Geneva University Hospital, Centre Medical Universitaire, Rue Michel-Servet, 1211, Geneva 4, Switzerland. ^[4] NEURIX SA, Geneva, Switzerland. ^[5] Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, Constance, Germany. ^[6] TNO, Zeist, The Netherlands. ^[7] BioMarin Pharmaceutical Inc., Leiden, The Netherlands. ^[8] Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. ^[9] Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany. ^[10] Department of Pathology and Immunology, Medical School, University of Geneva, Geneva, Switzerland. Karl-Heinz.Krause@unige.ch. ^[11] Department of Genetic and Laboratory Medicine, Geneva University Hospital, Centre Medical Universitaire, Rue Michel-Servet, 1211, Geneva 4, Switzerland. Karl-Heinz.Krause@unige.ch. ^[12]

主题词动物(Animals);细胞间通讯(Cell Communication);细胞分化(Cell Differentiation);细胞系(Cell Line);细胞存活(Cell Survival);共同培养技术(Coculture Techniques);药物评价, 临床前(Drug Evaluation, Preclinical);药物, 临床试用(Drugs, Investigational);环境监测(Environmental Monitoring);环境污染物(Environmental Pollutants);基因, 报告(Genes, Reporter);发光蛋白质类(Luminescent Proteins);小鼠(Mice);神经元(Neurons);神经毒素类(Neurotoxins);肽延伸因子1(Peptide Elongation Factor 1);多潜能干细胞(Pluripotent Stem Cells);启动区, 遗传(Promoter Regions, Genetic);间质细胞(Stromal Cells);微管蛋白(Tubulin)

DOI 10.1007/s00204-016-1690-2

PMID 27015953

发布时间 2019-12-10

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Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.

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Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.

Archives of toxicology

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