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首页> Journal of molecular and cellular cardiology> Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.

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作者： James W,McNamara ^[1] ; Amy,Li ^[2] ; Nicola J,Smith ^[3] ; Sean,Lal ^[2] ; Robert M,Graham ^[3] ; Kristina Bezold,Kooiker ^[4] ; Sabine J,van Dijk ^[5] ; Cristobal G Dos,Remedios ^[2] ; Samantha P,Harris ^[5] ; Roger,Cooke ^[6]

作者单位： Discipline of Anatomy & Histology, Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia. Electronic address: jmcn6970@uni.sydney.edu.au. ^[1] Discipline of Anatomy & Histology, Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia. ^[2] Molecular Cardiology Program, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia. ^[3] Department of Pediatrics (Cardiology), Cardiovascular Institute, Stanford University, CA 94304, USA. ^[4] Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721, USA. ^[5] Department of Biochemistry & Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158-2517, USA. ^[6]

关键词 Cardiac SRX Cardiac energetics Hypertrophic cardiomyopathy Myosin II ATPase Myosin binding protein-C (MyBP-C)Thick filament structure

主题词动物(Animals);心肌肌球蛋白(Cardiac Myosins);心肌病, 肥厚性(Cardiomyopathy, Hypertrophic);载体蛋白质类(Carrier Proteins);基因型(Genotype);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肌细胞, 心脏(Myocytes, Cardiac);磷酰化(Phosphorylation);肌节(Sarcomeres)

DOI 10.1016/j.yjmcc.2016.03.009

PMID 27021517

发布时间 2019-01-11

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Journal of molecular and cellular cardiology

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