ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.

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作者： Nobutaka,Sakae ^[1] ; Chia-Chen,Liu ^[1] ; Mitsuru,Shinohara ^[1] ; Jessica,Frisch-Daiello ^[2] ; Li,Ma ^[1] ; Yu,Yamazaki ^[1] ; Masaya,Tachibana ^[1] ; Linda,Younkin ^[1] ; Aishe,Kurti ^[1] ; Minerva M,Carrasquillo ^[1] ; Fanggeng,Zou ^[1] ; Daniel,Sevlever ^[1] ; Gina,Bisceglio ^[1] ; Ming,Gan ^[1] ; Romain,Fol ^[1] ; Patrick,Knight ^[1] ; Miao,Wang ^[2] ; Xianlin,Han ^[2] ; John D,Fryer ^[1] ; Michael L,Fitzgerald ^[3] ; Yasumasa,Ohyagi ^[4] ; Steven G,Younkin ^[1] ; Guojun,Bu ^[5] ; Takahisa,Kanekiyo ^[5]

作者单位： Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224. ^[1] Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827. ^[2] Lipid Metabolism Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, and. ^[3] Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan. ^[4] Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, bu.guojun@mayo.edu kanekiyo.takahisa@mayo.edu. ^[5]

关键词 ABCA7 APP BACE1 cognitive function lipid homeostasis neuron