Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/β-catenin signaling pathway.

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作者： Kehong,Zheng ^[1] ; Xinying,Zhou ^[2] ; Jinlong,Yu ^[1] ; Qiang,Li ^[1] ; Hui,Wang ^[3] ; Mingyi,Li ^[4] ; Ziyun,Shao ^[5] ; Feifei,Zhang ^[5] ; Yuhao,Luo ^[5] ; Zetao,Shen ^[5] ; Fei,Chen ^[1] ; Fujun,Shi ^[1] ; Chunhui,Cui ^[1] ; Dachuan,Zhao ^[1] ; Zhiqun,Lin ^[1] ; Wei,Zheng ^[1] ; Zhaowei,Zou ^[1] ; Zonghai,Huang ^[6] ; Liang,Zhao ^[7]

作者单位： Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ^[1] Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. ^[2] Department of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China. ^[3] Radiotherapy Department, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China. ^[4] Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China. ^[5] Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: drhuangzh@163.com. ^[6] Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Electronic address: liangsmu@foxmail.com. ^[7]

关键词 Colorectal cancer (CRC)Epithelial–mesenchymal transition (EMT)Frequently rearranged in advanced T-cell lymphomas protein (FRAT1)Wnt signaling pathway miR-490-3p