Carnosine decreased neuronal cell death through targeting glutamate system and astrocyte mitochondrial bioenergetics in cultured neuron/astrocyte exposed to OGD/recovery.

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第一作者： Li,Ouyang

第一单位： Key Laboratory of Laboratory Medicine, Ministry of Education and Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou 325035, PR China.

作者： Li,Ouyang ^[1] ; Yueyang,Tian ^[1] ; Yun,Bao ^[1] ; Huijuan,Xu ^[2] ; Jiaoyan,Cheng ^[1] ; Bingyu,Wang ^[1] ; Yao,Shen ^[3] ; Zhong,Chen ^[4] ; Jianxin,Lyu ^[1]

作者单位： Key Laboratory of Laboratory Medicine, Ministry of Education and Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou 325035, PR China. ^[1] Key Laboratory of Laboratory Medicine, Ministry of Education and Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou 325035, PR China; Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. ^[2] Key Laboratory of Laboratory Medicine, Ministry of Education and Zhejiang Provincial Key Laboratory of Medical Genetics, College of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou 325035, PR China. Electronic address: yueshen-2002@163.com. ^[3] Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China. ^[4]

关键词 Astrocyte-neuron lactate shuttle Carnosine Energy metabolism GABA Glutamate OGD/recovery