Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study.

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作者： Jan,Fox ^[1] ; Matthias,Kraemer ^[2] ; Thorsten,Schormann ^[3] ; Andreas,Dabringhaus ^[4] ; Jochen,Hirsch ^[5] ; Philipp,Eisele ^[6] ; Kristina,Szabo ^[7] ; Christel,Weiss ^[8] ; Michael,Amann ^[9] ; Katrin,Weier ^[10] ; Yvonne,Naegelin ^[11] ; Ludwig,Kappos ^[12] ; Achim,Gass ^[13]

作者单位： Universitätsmedizin Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany. J_Fox@web.de. ^[1] Hospital zum Heiligen Geist, Department for Early Rehabilitation, Kempen 47906, Germany. matthias.kraemer@krankenhaus-kempen.de. ^[2] Institute for Anatomy, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40001, Germany. thorsten@hirn.uni-duesseldorf.de. ^[3] Deutsches Institut für Medizinische Dokumentation und Information, Waisenhausgasse 36-38a, Köln 50676, Germany. Dabringhaus@dimdi.de. ^[4] Fraunhofer MEVIS, Institut für Bildgestützte Medizin, Universitätsallee 29, Bremen 28359, Germany. jochen.hirsch@mevis.fraunhofer.de. ^[5] Universitätsmedizin Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany. eisele@neuro.ma.uni-heidelberg.de. ^[6] Universitätsmedizin Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany. szabo@neuro.ma.uni-heidelberg.de. ^[7] Department of Biometry and Statistics, Medical Faculty Mannheim, Ruprecht-Karls University Heidelberg, Mannheim 68167, Germany. Christel.Weiss@medma.uni-heidelberg.de. ^[8] MIAC, Basel, Universitätsspital Basel, Mittlere Strasse 83, Basel 4056, Switzerland. michael.amann@usb.ch. ^[9] Neurology, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel, Petersgraben 4, Basel 4052, Switzerland. katrin.weier@usb.ch. ^[10] Neurology, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel, Petersgraben 4, Basel 4052, Switzerland. yvonne.naegelin@usb.ch. ^[11] Neurology, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel, Petersgraben 4, Basel 4052, Switzerland. ludwig.kappos@usb.ch. ^[12] Universitätsmedizin Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany. achim.gass@medma.uni-heidelberg.de. ^[13]

关键词 Wallerian degeneration corpus callosum lateral geniculate nucleus lesion multiple sclerosis regional brain atrophy retrograde degeneration shrinking voxel