Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.

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作者： F,Ebstein ^[1] ; K,Textoris-Taube ^[1] ; C,Keller ^[1] ; R,Golnik ^[1] ; N,Vigneron ^[2] ; B J,Van den Eynde ^[2] ; B,Schuler-Thurner ^[3] ; D,Schadendorf ^[4] ; F K M,Lorenz ^[5] ; W,Uckert ^[5] ; S,Urban ^[6] ; A,Lehmann ^[1] ; N,Albrecht-Koepke ^[1] ; K,Janek ^[1] ; P,Henklein ^[1] ; A,Niewienda ^[1] ; P M,Kloetzel ^[1] ; M,Mishto ^[1]

作者单位： Institut für Biochemie, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. ^[1] Ludwig Institute for Cancer Research, WELBIO (Walloon Excellence in Life Sciences and Biotechnology) and the de Duve Institute, Université catholique de Louvain, Place de l'Université 1, B-1200 Brussels, Belgium. ^[2] Department of Dermatology, Universitätsklinikum Erlangen, Ulmenweg 18, D-91052 Erlangen, Germany. ^[3] Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen D - 45122 Essen, Germany &German Cancer Consortium (DKTK), Hufelandstraße 55, D-69120 Heidelberg, Germany. ^[4] Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13092 Berlin, Germany. ^[5] Institute of Biology, Humboldt University Berlin, Charitéplatz 1, D-10115 Berlin, Germany. ^[6]

主题词算法(Algorithms);选择性剪接(Alternative Splicing);抗原呈递(Antigen Presentation);抗原(Antigens);抗原, 肿瘤(Antigens, Neoplasm);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);病例对照研究(Case-Control Studies);催化作用(Catalysis);细胞系, 肿瘤(Cell Line, Tumor);表位(Epitopes);表位, T淋巴细胞(Epitopes, T-Lymphocyte);人类(Humans);干扰素γ(Interferon-gamma);黑素细胞(Melanocytes);黑色素瘤(Melanoma);肽类(Peptides);概率(Probability);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);gp100黑色素瘤抗原(gp100 Melanoma Antigen)

DOI 10.1038/srep24032

PMID 27049119

发布时间 2018-11-13

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Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.

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Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.

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