Proteogenomics: Integrating Next-Generation Sequencing and Mass Spectrometry to Characterize Human Proteomic Variation.

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第一作者： Gloria M,Sheynkman

第一单位： Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215; email: gloriam_sheynkman@dfci.harvard.edu.;Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.;Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706; email: mshort@chem.wisc.edu , cesnik@wisc.edu.

作者： Gloria M,Sheynkman ^[1] ; Michael R,Shortreed ^[2] ; Anthony J,Cesnik ^[2] ; Lloyd M,Smith ^[3]

作者单位： Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215; email: gloriam_sheynkman@dfci.harvard.edu.;Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.;Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706; email: mshort@chem.wisc.edu , cesnik@wisc.edu. ^[1] Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706; email: mshort@chem.wisc.edu , cesnik@wisc.edu. ^[2] Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706; email: mshort@chem.wisc.edu , cesnik@wisc.edu.;Genome Center of Wisconsin, University of Wisconsin, Madison, Wisconsin 53706; email: smith@chem.wisc.edu. ^[3]

关键词 alternative splicing customized protein databases genetic variation isoforms novel splice junction polymorphism proteoform proteomics sample-specific databases single amino acid variant

主题词碱基序列(Base Sequence);遗传变异(Genetic Variation);人类(Humans);质谱分析法(Mass Spectrometry);蛋白质类(Proteins)

DOI 10.1146/annurev-anchem-071015-041722

PMID 27049631

发布时间 2024-06-10

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