Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.

导出原文传递

翻译打印收藏纠错

第一作者： Paolo,Innocenti

第一单位： Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research , 15 Cotswold Road, Sutton, London, SM2 5NG, United Kingdom.

作者： Paolo,Innocenti ^[1] ; Hannah L,Woodward ^[1] ; Savade,Solanki ^[1] ; Sébastien,Naud ^[1] ; Isaac M,Westwood ^[1] ; Nora,Cronin ^[1] ; Angela,Hayes ^[1] ; Jennie,Roberts ^[1] ; Alan T,Henley ^[1] ; Ross,Baker ^[1] ; Amir,Faisal ^[1] ; Grace Wing-Yan,Mak ^[1] ; Gary,Box ^[1] ; Melanie,Valenti ^[1] ; Alexis,De Haven Brandon ^[1] ; Lisa,O'Fee ^[1] ; Harry,Saville ^[1] ; Jessica,Schmitt ^[1] ; Berry,Matijssen ^[1] ; Rosemary,Burke ^[1] ; Rob L M,van Montfort ^[1] ; Florence I,Raynaud ^[1] ; Suzanne A,Eccles ^[1] ; Spiros,Linardopoulos ^[1] ; Julian,Blagg ^[1] ; Swen,Hoelder

作者单位： Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research , 15 Cotswold Road, Sutton, London, SM2 5NG, United Kingdom. ^[1]

主题词细胞周期蛋白质类(Cell Cycle Proteins);药物发现(Drug Discovery);分子结构(Molecular Structure);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases)

DOI 10.1021/acs.jmedchem.5b01811

PMID 27055065

发布时间 2022-01-29

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交