High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition.
第一作者:
Laurel T,Bate-Eya
第一单位:
Department of Oncogenomics, University of Amsterdam, Amsterdam, The Netherlands.
作者:
主题词
动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);细胞色素c类(Cytochromes c);药物评价, 临床前(Drug Evaluation, Preclinical);女(雌)性(Female);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);小鼠(Mice);线粒体(Mitochondria);神经母细胞瘤(Neuroblastoma);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);磺胺类(Sulfonamides);治疗结果(Treatment Outcome);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.18632/oncotarget.8547
PMID
27056887
发布时间
2018-11-13
- 浏览7
Oncotarget
27946-58页
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